TCA cycle; cancer metabolism; cancer signaling; epithelial transformation; fumarate hydratase; metabolic reprogramming; papillary carcinoma; rapamycin; renal cancer; renal cysts

Renal cell carcinomas (RCCs) are common cancers diagnosed in more than 350,000 people each year worldwide. Several pathways are de-regulated in RCCs, including mTORC1. However, how mTOR drives tumorigenesis in this context is unknown. The lack of …