Discrete modeling; Gene regulatory networks; Hybrid system; Quasi-steady state approximation; Stochastic noise; Biochemistry; Structural Biology; Organic Chemistry; Computational Mathematics

On the impact of discreteness and abstractions on modelling noise in gene regulatory networks

In this paper, we explore the impact of different forms of model abstraction and the role of discreteness on the dynamical behaviour of a simple model of gene regulation where a transcriptional repressor negatively regulates its own expression. We …