Heuristics, optimizations, and parallelism for protein structure prediction in CLP(ℱD)

Abstract

The paper describes a constraint-based solution to the protein folding problem on face-centered cubic lattices - a biologically meaningful approximation of the general protein folding problem. The paper improves the results presented in [15] and introduces new ideas for improving efficiency: (i) proper reorganization of the constraint structure; (ii) development of novel, both general and problem-specific, heuristics; (iii) exploitation of parallelism. Globally, we obtain a speed up in the order of 60 w.r.t. [15]. We show how these results can be employed to solve the folding problem for large proteins containing subsequences whose conformation is already known. Copyright 2005 ACM.

Publication
PPDP’05 - Proceedings of the Seventh ACM SIGPLAN Conference on Principles and Practice of Declarative Programming
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