© Springer International Publishing AG 2017. Search-based testing is widely used to find bugs in models of complex Cyber-Physical Systems. Latest research efforts have improved this approach by casting it as a falsification procedure of formally specified temporal properties, exploiting the robustness semantics of Signal Temporal Logic. The scaling of this approach to highly complex engineering systems requires efficient falsification procedures, which should be applicable also to black box models. Falsification is also exacerbated by the fact that inputs are often time-dependent functions. We tackle the falsification of formal properties of complex black box models of Cyber-Physical Systems, leveraging machine learning techniques from the area of Active Learning. Tailoring these techniques to the falsification problem with time-dependent, functional inputs, we show a considerable gain in computational effort, by reducing the number of model simulations needed. The effectiveness of the proposed approach is discussed on a challenging industrial-level benchmark from automotive.